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Epidemiology and the concept of causation in multifactorial diseases.

Regulatory toxicology and pharmacology : RTP

Gori GB.
PMID: 2756173
Regul Toxicol Pharmacol. 1989 Jun;9(3):263-72. doi: 10.1016/0273-2300(89)90065-2.

Unlike infectious diseases of the past, diseases prevalent in modern industrialized societies have multifactorial origins whose complexity so far has defied an integrated scientific understanding. Their epidemiologic investigation suffers from the conceptual inability of formulating plausible causal hypotheses that...

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Gori GB. Epidemiology and the concept of causation in multifactorial diseases. Regul Toxicol Pharmacol. 1989;9(3):263-72doi: 10.1016/0273-2300(89)90065-2.
Gori, G. B. (1989). Epidemiology and the concept of causation in multifactorial diseases. Regulatory toxicology and pharmacology : RTP, 9(3), 263-72. https://doi.org/10.1016/0273-2300(89)90065-2
Gori, G B. "Epidemiology and the concept of causation in multifactorial diseases." Regulatory toxicology and pharmacology : RTP vol. 9,3 (1989): 263-72. doi: https://doi.org/10.1016/0273-2300(89)90065-2
Gori GB. Epidemiology and the concept of causation in multifactorial diseases. Regul Toxicol Pharmacol. 1989 Jun;9(3):263-72. doi: 10.1016/0273-2300(89)90065-2. PMID: 2756173.
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Corrigendum to "Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics" [Regul. Toxicol. Pharmacol. (2017) 221-230].

Regulatory toxicology and pharmacology : RTP

de Zafra CLZ, Sasseville VG, Matsumoto S, Freichel C, Milton M, MacLachlan TK, Farman C, Raymond I, Gupta S, Newton R, Atzpodien EA, Thackaberry EA.
PMID: 28431771
Regul Toxicol Pharmacol. 2017 Aug;88:364. doi: 10.1016/j.yrtph.2017.04.006. Epub 2017 Apr 18.

No abstract available.

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de Zafra CLZ, Sasseville VG, Matsumoto S, et al. Corrigendum to "Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics" [Regul. Toxicol. Pharmacol. (2017) 221-230]. Regul Toxicol Pharmacol. 2017;88:364doi: 10.1016/j.yrtph.2017.04.006.
de Zafra, C. L. Z., Sasseville, V. G., Matsumoto, S., Freichel, C., Milton, M., MacLachlan, T. K., Farman, C., Raymond, I., Gupta, S., Newton, R., Atzpodien, E. A., & Thackaberry, E. A. (2017). Corrigendum to "Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics" [Regul. Toxicol. Pharmacol. (2017) 221-230]. Regulatory toxicology and pharmacology : RTP, 88364. https://doi.org/10.1016/j.yrtph.2017.04.006
de Zafra, Christina L Zuch, et al. "Corrigendum to "Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics" [Regul. Toxicol. Pharmacol. (2017) 221-230]." Regulatory toxicology and pharmacology : RTP vol. 88 (2017): 364. doi: https://doi.org/10.1016/j.yrtph.2017.04.006
de Zafra CLZ, Sasseville VG, Matsumoto S, Freichel C, Milton M, MacLachlan TK, Farman C, Raymond I, Gupta S, Newton R, Atzpodien EA, Thackaberry EA. Corrigendum to "Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics" [Regul. Toxicol. Pharmacol. (2017) 221-230]. Regul Toxicol Pharmacol. 2017 Aug;88:364. doi: 10.1016/j.yrtph.2017.04.006. Epub 2017 Apr 18. PMID: 28431771.
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Science and politics: from science to decision making.

Regulatory toxicology and pharmacology : RTP

Petry T, Löfstedt RE, Dietrich DR.
PMID: 16198034
Regul Toxicol Pharmacol. 2006 Feb;44(1):1-3. doi: 10.1016/j.yrtph.2005.08.004. Epub 2005 Sep 28.

No abstract available.

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Petry T, Löfstedt RE, Dietrich DR. Science and politics: from science to decision making. Regul Toxicol Pharmacol. 2005;44(1):1-3doi: 10.1016/j.yrtph.2005.08.004.
Petry, T., Löfstedt, R. E., & Dietrich, D. R. (2006). Science and politics: from science to decision making. Regulatory toxicology and pharmacology : RTP, 44(1), 1-3. https://doi.org/10.1016/j.yrtph.2005.08.004
Petry, Thomas, et al. "Science and politics: from science to decision making." Regulatory toxicology and pharmacology : RTP vol. 44,1 (2006): 1-3. doi: https://doi.org/10.1016/j.yrtph.2005.08.004
Petry T, Löfstedt RE, Dietrich DR. Science and politics: from science to decision making. Regul Toxicol Pharmacol. 2006 Feb;44(1):1-3. doi: 10.1016/j.yrtph.2005.08.004. Epub 2005 Sep 28. PMID: 16198034.
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Appendix: Alternative Tier 2 Health Effects Testing Requirements for Gasoline and Oxygenated Gasolines.

Regulatory toxicology and pharmacology : RTP

Clark CR.
PMID: 25149684
Regul Toxicol Pharmacol. 2014 Aug 19; doi: 10.1016/j.yrtph.2014.08.006. Epub 2014 Aug 19.

No abstract available.

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Clark CR. Appendix: Alternative Tier 2 Health Effects Testing Requirements for Gasoline and Oxygenated Gasolines. Regul Toxicol Pharmacol. 2014;doi: 10.1016/j.yrtph.2014.08.006.
Clark, C. R. (2014). Appendix: Alternative Tier 2 Health Effects Testing Requirements for Gasoline and Oxygenated Gasolines. Regulatory toxicology and pharmacology : RTP, . https://doi.org/10.1016/j.yrtph.2014.08.006
Clark, Charles R. "Appendix: Alternative Tier 2 Health Effects Testing Requirements for Gasoline and Oxygenated Gasolines." Regulatory toxicology and pharmacology : RTP vol. (2014). doi: https://doi.org/10.1016/j.yrtph.2014.08.006
Clark CR. Appendix: Alternative Tier 2 Health Effects Testing Requirements for Gasoline and Oxygenated Gasolines. Regul Toxicol Pharmacol. 2014 Aug 19; doi: 10.1016/j.yrtph.2014.08.006. Epub 2014 Aug 19. PMID: 25149684.
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1999 international course on the safety assessment of medicines .

Regulatory toxicology and pharmacology : RTP

[No authors listed]
PMID: 10051424
Regul Toxicol Pharmacol. 1999 Feb;29(1):98. doi: 10.1006/rtph.1998.1285.

No abstract available.

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1999 international course on the safety assessment of medicines . Regul Toxicol Pharmacol. 1999;29(1):98doi: 10.1006/rtph.1998.1285.
(1999). 1999 international course on the safety assessment of medicines . Regulatory toxicology and pharmacology : RTP, 29(1), 98. https://doi.org/10.1006/rtph.1998.1285
"1999 international course on the safety assessment of medicines ." Regulatory toxicology and pharmacology : RTP vol. 29,1 (1999): 98. doi: https://doi.org/10.1006/rtph.1998.1285
1999 international course on the safety assessment of medicines . Regul Toxicol Pharmacol. 1999 Feb;29(1):98. doi: 10.1006/rtph.1998.1285. PMID: 10051424.
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The dilemma of causation in toxic torts.

Regulatory toxicology and pharmacology : RTP

Harter PJ.
PMID: 3726176
Regul Toxicol Pharmacol. 1986 Jun;6(2):103-7. doi: 10.1016/0273-2300(86)90027-9.

No abstract available.

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Harter PJ. The dilemma of causation in toxic torts. Regul Toxicol Pharmacol. 1986;6(2):103-7doi: 10.1016/0273-2300(86)90027-9.
Harter, P. J. (1986). The dilemma of causation in toxic torts. Regulatory toxicology and pharmacology : RTP, 6(2), 103-7. https://doi.org/10.1016/0273-2300(86)90027-9
Harter, P J. "The dilemma of causation in toxic torts." Regulatory toxicology and pharmacology : RTP vol. 6,2 (1986): 103-7. doi: https://doi.org/10.1016/0273-2300(86)90027-9
Harter PJ. The dilemma of causation in toxic torts. Regul Toxicol Pharmacol. 1986 Jun;6(2):103-7. doi: 10.1016/0273-2300(86)90027-9. PMID: 3726176.
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Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals.

Regulatory toxicology and pharmacology : RTP

Bourdon-Lacombe JA, Moffat ID, Deveau M, Husain M, Auerbach S, Krewski D, Thomas RS, Bushel PR, Williams A, Yauk CL.
PMID: 25944780
Regul Toxicol Pharmacol. 2015 Jul;72(2):292-309. doi: 10.1016/j.yrtph.2015.04.010. Epub 2015 May 02.

Toxicogenomics promises to be an important part of future human health risk assessment of environmental chemicals. The application of gene expression profiles (e.g., for hazard identification, chemical prioritization, chemical grouping, mode of action discovery, and quantitative analysis of response)...

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Bourdon-Lacombe JA, Moffat ID, Deveau M, et al. Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals. Regul Toxicol Pharmacol. 2015;72(2):292-309doi: 10.1016/j.yrtph.2015.04.010.
Bourdon-Lacombe, J. A., Moffat, I. D., Deveau, M., Husain, M., Auerbach, S., Krewski, D., Thomas, R. S., Bushel, P. R., Williams, A., & Yauk, C. L. (2015). Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals. Regulatory toxicology and pharmacology : RTP, 72(2), 292-309. https://doi.org/10.1016/j.yrtph.2015.04.010
Bourdon-Lacombe, Julie A, et al. "Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals." Regulatory toxicology and pharmacology : RTP vol. 72,2 (2015): 292-309. doi: https://doi.org/10.1016/j.yrtph.2015.04.010
Bourdon-Lacombe JA, Moffat ID, Deveau M, Husain M, Auerbach S, Krewski D, Thomas RS, Bushel PR, Williams A, Yauk CL. Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals. Regul Toxicol Pharmacol. 2015 Jul;72(2):292-309. doi: 10.1016/j.yrtph.2015.04.010. Epub 2015 May 02. PMID: 25944780; PMCID: PMC7970737.
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Corrigendum to "Quantitative analysis of menthol and identification of other flavoring ingredients in capsule cigarettes marketed in Korea" [Regul. Toxicol. Pharmacol. 92C (2018) 420-428].

Regulatory toxicology and pharmacology : RTP

Kim HS, Pack EC, Koo YJ, Lee YJ, Sung DK, Lee SH, Kim YS, Kwon KH, Lim KM, Jang DY, Choi DW.
PMID: 29429759
Regul Toxicol Pharmacol. 2018 Jun;95:448. doi: 10.1016/j.yrtph.2018.01.014. Epub 2018 Feb 21.

No abstract available.

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Kim HS, Pack EC, Koo YJ, et al. Corrigendum to "Quantitative analysis of menthol and identification of other flavoring ingredients in capsule cigarettes marketed in Korea" [Regul. Toxicol. Pharmacol. 92C (2018) 420-428]. Regul Toxicol Pharmacol. 2018;95:448doi: 10.1016/j.yrtph.2018.01.014.
Kim, H. S., Pack, E. C., Koo, Y. J., Lee, Y. J., Sung, D. K., Lee, S. H., Kim, Y. S., Kwon, K. H., Lim, K. M., Jang, D. Y., & Choi, D. W. (2018). Corrigendum to "Quantitative analysis of menthol and identification of other flavoring ingredients in capsule cigarettes marketed in Korea" [Regul. Toxicol. Pharmacol. 92C (2018) 420-428]. Regulatory toxicology and pharmacology : RTP, 95448. https://doi.org/10.1016/j.yrtph.2018.01.014
Kim, Hyung Soo, et al. "Corrigendum to "Quantitative analysis of menthol and identification of other flavoring ingredients in capsule cigarettes marketed in Korea" [Regul. Toxicol. Pharmacol. 92C (2018) 420-428]." Regulatory toxicology and pharmacology : RTP vol. 95 (2018): 448. doi: https://doi.org/10.1016/j.yrtph.2018.01.014
Kim HS, Pack EC, Koo YJ, Lee YJ, Sung DK, Lee SH, Kim YS, Kwon KH, Lim KM, Jang DY, Choi DW. Corrigendum to "Quantitative analysis of menthol and identification of other flavoring ingredients in capsule cigarettes marketed in Korea" [Regul. Toxicol. Pharmacol. 92C (2018) 420-428]. Regul Toxicol Pharmacol. 2018 Jun;95:448. doi: 10.1016/j.yrtph.2018.01.014. Epub 2018 Feb 21. PMID: 29429759.
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Use of the kinetically-derived maximum dose: Opportunities for delivering 3Rs benefits.

Regulatory toxicology and pharmacology : RTP

Sewell F, Kimber I, Boobis AR.
PMID: 32679052
Regul Toxicol Pharmacol. 2020 Oct;116:104734. doi: 10.1016/j.yrtph.2020.104734. Epub 2020 Jul 15.

No abstract available.

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Sewell F, Kimber I, Boobis AR. Use of the kinetically-derived maximum dose: Opportunities for delivering 3Rs benefits. Regul Toxicol Pharmacol. 2020;116:104734doi: 10.1016/j.yrtph.2020.104734.
Sewell, F., Kimber, I., & Boobis, A. R. (2020). Use of the kinetically-derived maximum dose: Opportunities for delivering 3Rs benefits. Regulatory toxicology and pharmacology : RTP, 116104734. https://doi.org/10.1016/j.yrtph.2020.104734
Sewell, Fiona, et al. "Use of the kinetically-derived maximum dose: Opportunities for delivering 3Rs benefits." Regulatory toxicology and pharmacology : RTP vol. 116 (2020): 104734. doi: https://doi.org/10.1016/j.yrtph.2020.104734
Sewell F, Kimber I, Boobis AR. Use of the kinetically-derived maximum dose: Opportunities for delivering 3Rs benefits. Regul Toxicol Pharmacol. 2020 Oct;116:104734. doi: 10.1016/j.yrtph.2020.104734. Epub 2020 Jul 15. PMID: 32679052.
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The use of epidemiological data in risk assessment.

Regulatory toxicology and pharmacology : RTP

Swaen GM.
PMID: 3222484
Regul Toxicol Pharmacol. 1988 Dec;8(4):422-30. doi: 10.1016/0273-2300(88)90041-4.

Next to toxicological data, epidemiological studies form the scientific basis for risk assessment. Both approaches have their particular advantages and limitations. The most important limitation of epidemiological studies is the lack of exact data on past exposures. Their most...

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Swaen GM. The use of epidemiological data in risk assessment. Regul Toxicol Pharmacol. 1988;8(4):422-30doi: 10.1016/0273-2300(88)90041-4.
Swaen, G. M. (1988). The use of epidemiological data in risk assessment. Regulatory toxicology and pharmacology : RTP, 8(4), 422-30. https://doi.org/10.1016/0273-2300(88)90041-4
Swaen, G M. "The use of epidemiological data in risk assessment." Regulatory toxicology and pharmacology : RTP vol. 8,4 (1988): 422-30. doi: https://doi.org/10.1016/0273-2300(88)90041-4
Swaen GM. The use of epidemiological data in risk assessment. Regul Toxicol Pharmacol. 1988 Dec;8(4):422-30. doi: 10.1016/0273-2300(88)90041-4. PMID: 3222484.
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Screening of different cytotoxicity methods for the assessment of ENDS toxicity relative to tobacco cigarettes.

Regulatory toxicology and pharmacology : RTP

Caruso M, Emma R, Rust S, Distefano A, Carota G, Pulvirenti R, Polosa R, Li Volti G.
PMID: 34314750
Regul Toxicol Pharmacol. 2021 Oct;125:105018. doi: 10.1016/j.yrtph.2021.105018. Epub 2021 Jul 24.

Electronic Nicotine Delivery Systems (ENDS), i.e., electronic-cigarettes (e-cigs) and Tobacco Heating Products (THPs), are rapidly growing in popularity. Nonetheless, comprehensive quality and safety requirements for regulatory purposes are still under development. Cytotoxicity studies are important initial steps in appraising...

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Caruso M, Emma R, Rust S, et al. Screening of different cytotoxicity methods for the assessment of ENDS toxicity relative to tobacco cigarettes. Regul Toxicol Pharmacol. 2021;125:105018doi: 10.1016/j.yrtph.2021.105018.
Caruso, M., Emma, R., Rust, S., Distefano, A., Carota, G., Pulvirenti, R., Polosa, R., & Li Volti, G. (2021). Screening of different cytotoxicity methods for the assessment of ENDS toxicity relative to tobacco cigarettes. Regulatory toxicology and pharmacology : RTP, 125105018. https://doi.org/10.1016/j.yrtph.2021.105018
Caruso, Massimo, et al. "Screening of different cytotoxicity methods for the assessment of ENDS toxicity relative to tobacco cigarettes." Regulatory toxicology and pharmacology : RTP vol. 125 (2021): 105018. doi: https://doi.org/10.1016/j.yrtph.2021.105018
Caruso M, Emma R, Rust S, Distefano A, Carota G, Pulvirenti R, Polosa R, Li Volti G. Screening of different cytotoxicity methods for the assessment of ENDS toxicity relative to tobacco cigarettes. Regul Toxicol Pharmacol. 2021 Oct;125:105018. doi: 10.1016/j.yrtph.2021.105018. Epub 2021 Jul 24. PMID: 34314750.
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Physiologically based pharmacokinetic (PBPK) modeling of perfluorohexane sulfonate (PFHxS) in humans.

Regulatory toxicology and pharmacology : RTP

Sweeney LM.
PMID: 34933042
Regul Toxicol Pharmacol. 2021 Dec 18;129:105099. doi: 10.1016/j.yrtph.2021.105099. Epub 2021 Dec 18.

Per- and polyfluoroalkyl substances (PFAS) are persistent, man-made compounds prevalent in the environment and consistently identified in human biomonitoring samples. In particular, perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS) have been identified at U.S....

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Sweeney LM. Physiologically based pharmacokinetic (PBPK) modeling of perfluorohexane sulfonate (PFHxS) in humans. Regul Toxicol Pharmacol. 2021;129:105099doi: 10.1016/j.yrtph.2021.105099.
Sweeney, L. M. (2021). Physiologically based pharmacokinetic (PBPK) modeling of perfluorohexane sulfonate (PFHxS) in humans. Regulatory toxicology and pharmacology : RTP, 129105099. https://doi.org/10.1016/j.yrtph.2021.105099
Sweeney, Lisa M. "Physiologically based pharmacokinetic (PBPK) modeling of perfluorohexane sulfonate (PFHxS) in humans." Regulatory toxicology and pharmacology : RTP vol. 129 (2021): 105099. doi: https://doi.org/10.1016/j.yrtph.2021.105099
Sweeney LM. Physiologically based pharmacokinetic (PBPK) modeling of perfluorohexane sulfonate (PFHxS) in humans. Regul Toxicol Pharmacol. 2021 Dec 18;129:105099. doi: 10.1016/j.yrtph.2021.105099. Epub 2021 Dec 18. PMID: 34933042.
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Showing 1 to 12 of 310 entries